AffyImmune Therapeutics, Incorporated, a start-up, located in Newton, Massachusetts and soon to be moving to Framingham, Massachusetts, specializes in developing affinity tuned Chimeric Antigen Receptor (“CAR”) T cell therapy in solid tumors. Its proprietary technology may significantly improve the existing CAR-T cell therapy by extending the target of CAR-T therapies to solid tumors using a novel molecule and tuning down the affinity from picomolar to micromolar level to lower the on-target off-tumor toxicity. Presently the company has two products in the pipe line undergoing clinical trials.
The company seeks an experienced, hands-on Scientist / Senior Research Scientist to be instrumental in setting up a laboratory and conducting product research and development in a small team environment. Requires individual with hands-on bench chemistry expertise in cell culture, FACS analysis and basic protein chemistry assay development skills.. A proven knowledge of molecular biology required, ideally with experience conducting gene editing and viral transduction to generate stable cell lines. Some background in immunology and primary or T cell characterization is also highly desirable.